Promotes Strong Healthy Bones With Calcium, Ipriflavone, Folic Acid & More

Ipriflavone promotes the absorption of calcium into bone. It also helps prevent bone breakdown. Clinical studies, including numerous double-blind studies, have plainly shown that long-term treatment with ipriflavone (coupled with 1,000 mg supplemental calcium per day) is both safe and effective in halting bone loss in postmenopausal women or in women who have had their ovaries removed. Ipriflavone has also been found to improve bone density in many cases of osteoporosis. ^{1 2 3 4 5 6}

Maintain Stronger Bones

Are all calcium formulas alike? There are some important elements that may affect the way your body uses calcium. To help you get the most out of our supplements, we included synergistic compounds that prepare your body for proper calcium absorption and utilization. We’ve included ipriflavone, a leading edge nutrient only recently available, that promotes the healthy process of incorporating calcium into bone. Also included is vanadium, which is a bone-seeking, ultra-trace mineral, folic acid, vitamin B-12 and a special metabolite of vitamin B-6, which all support healthy calcium and bone metabolism. The Bone Builder formula also contains a highly absorbable form of calcium, as a calcium citrate/malate carbonate complex. People of all ages should support healthy bones with regular exercise, and a healthy diet including sufficient calcium. Take advantage of the newest research in bone health with Bone Formula.

How can I support the way my body maintains healthy calcium levels?

Promotes Bone Formation

Bone Builder is a high quality nutritional supplement based on the isoflavone derivative ipriflavone. Small amounts of ipriflavone occurs naturally in many foods. More than 60 double-blind placebo controlled clinical studies, involving over 3,000 participants in Italy, Japan, and Hungary, have shown that ipriflavone, along with calcium and vitamin D, significantly promotes bone health and strong bones.

An in vitro (laboratory tissue culture research) examination of the effect of ipriflavone and its metabolites on healthy bones resulted in interesting findings. Ipriflavone and one of its metabolites increased alkaline phosphatase activity (an enzyme used by osteoblast cells to lay down more calcium and phosphorus in bone), while another metabolite enhanced collagen formation, which is the protein foundation of bone.

Contains More Absorbable Calcium

Bone Builder also contains a unique form of calcium called calcium citrate malate carbonate complex (CCMC), which is a mixture of calcium combined primarily with citric acid and malic acid. Both of these organic acids are also involved in key energy producing pathways in the body.

Nutritional research has consistently shown that CCMC provides superior calcium absorption over other single forms of calcium; this formula provides extra elemental calcium in this form in two tablets taken twice daily.

Vanadium is an ultra-trace element, which occurs in the average diet in amounts of 15-30 micrograms per day. Research suggests that it plays a role in building bones and teeth. Bone Builder supplies 100 micrograms of vanadium per day.

Population studies have generally found that these three B vitamins help lower homocysteine levels in the blood, though it has not yet been substantiated as to whether this will have an impact on bone or cardiovascular health in the long term.

A whole foods diet rich in fruits, vegetables, high quality protein, high quality essential fats, and pure water, plus an active lifestyle, combined with Bone Builder will provide powerful tools for the maintenance of bone health that can last a lifetime. †

References:
1. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 199:61:S23–7 [includes review].
2. Head KA. Ipriflavone: an important bone-building isoflavone. Altern Med Rev 1999;4:10–22 [review].
3. Avioli LV. The future of ipriflavone in the management of osteoporotic syndromes. Calcif Tissue Int 1997;61 Suppl 1:S33–5 [review].
4. Adami S, Bufalino L, Cervetti R, et al. Ipriflavone prevents radial bone loss in postmenopausal women with low bone mass over 2 years. Osteoporosis Int 1997;7:119–25.
5. Nozaki M, Hashimoto K, Inoue Y, et al. Treatment of bone loss in oophorectomized women with a combination of ipriflavone and conjugated equine estrogen. Int J Gynaecol Obstet 1998;62:69–75.
6. Gennari C, Adami S, Agnusdei D, et al. Effect of chronic treatment with ipriflavone in postmenopausal women with low bone mass. Calcif Tissue Int 1997;61:S19–22.
7. Tsutsumi N, Kawashima K, Nagata H, et al. Effects of KCA-098 on bone metabolism: comparison with those of ipriflavone. Jpn J Pharmacol 1994; 65
8. Benvenuti S, Tanini A, Frediani U, et al. Effects of ipriflavone and its metabolites on a clonal osteoblastic cell line. J Bone Miner Res 1991; 6
9. Agnusdei D, Gennari C, Bufalino L. Prevention of early postmenopausal bone loss using low doses of conjugated estrogens and the non-hormonal, bone-active drug ipriflavone. Osteoporosis Int 1995; 5
10. Sato Y. Abnormal bone and calcium metabolism in patients after stroke. Arch Phys Med Rehabil 2000 Jan; 81 (1)
11. Bostom AG, Silbershatz IH, Rosenberg IH, et al. Non-fasting plasma total homocysteine levels and all cause and cardiovascular disease mortality in elderly Framingham men and women. Arch Intern Med 1999; 159:1077-80
12. Amano R, Enomoto S, Nobuta M, et al. Bone uptake of vanadium in mice: simultaneous tracing of V, Se, Sr, Y, Zr, Ru, and Rh using a radioactive multitracer. J Trace Elem Med Biol 1996Sep;10(3):145-8.
13. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61:S23-S27
14. Krumdieck CL, Prince CW. Mechanisms of homocysteine toxicity on connective tissues:implications for the morbidity of aging.J Nutr 2000 Feb;130(2S /syook):354S-368S
15. Miller J, Smith D, Flora L, et al. Calcium absorption from calcium carbonate and a new form of calcium (CCM) in healthy male and female adolescents. Am J Clin Nutr 1988;48:1291–4.

DIRECTIONS: Two tablets twice a day. Formulated in the exclusive PhytoZyme™ base of plant enzymes for bioavailability and over 30 synergistic fruit, vegetable and herbal concentrates for "extra" phytonutrient cofactors.

Contains no artificial preservatives, sugar, starch, caffeine, salt, wheat, gluten, yeast, corn, milk, egg, shellfish, soya derivatives, artificial sweetening, flavoring or coloring agents. Contains no ingredients from animal sources. This product is not tested on animals.

Click Here For Ingredients & Label Information

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.